1、 Purpose:
Used for automatic microbial colony counting analysis, inhibition zone measurement, antibiotic susceptibility analysis, antibiotic potency analysis, lactobacillus potency analysis, and automatic particle counting analysis in microscopic images.

2、 Main technical indicators
1. Imaging device
(1) Equipped with a solid-state drive computer and a large depth of field 8-megapixel (3264x2448 pixels) color camera with autofocus, it has macro shooting characteristics. Fully enclosed dark box to eliminate environmental stray light interference. Equipped with dual LED light source color scanning imaging capability, automatic focusing, adjustable brightness, and optical resolution40 million pixelsWhen scanning with uniform backlight or dark field, the resolution error is ≤ 0.01mm, and colonies with a resolution of ≥ 0.05mm can be identified.
(2) Flexible shadowless light source with adjustable upper light source, lower light source, and dual light source,5W high-power 275nm+395nm dual wavelength ultraviolet light illumination (used for cavity disinfection and UV mutagenesis),It can be freely combined and independently switched to create a clear suspended dark field colony imaging effect, highlighting colony morphology and obtaining the best colony imaging, achieving intelligent recognition and counting in a foolproof manner.
(3) Suitable culture dish: 50-130mm (poured, coated, 3M paper sheet, membrane filter, spiral inoculation dish).
2. Colony count analysis
（1）★Automatically generate batch processing wizard to achieve one click automatic countingSmartdownTM colony intelligent recognition technology has the characteristic of automatic enhancement of colony targets, which can automatically identify large-scale clustered and chain shaped adhered long rod-shaped bacteria (microscopic morphology of large adhered Escherichia coli, bacterial spores) and various types of colonies on petri dishes (including Staphylococcus aureus count (GB4789.10-2016), Escherichia coli group determination (GB4789.3-2016), etc.).
(2) The automatic counting accuracy is ≥ 96.5%, with a maximum monitoring correction of 3.5%, achieving 100% accuracy. Analysis and statistical speed: 150-1000 colonies/s (counting and analysis takes 1-4 seconds).
（3）★Automatically segment long, circular, and other colony targets that adhere to each other in patchesUsers can choose to split or not split. It is also possible to manually segment and merge colony target images. Mouse click correction, seamless removal of grids and text, automatic removal of impurities, effective support for complex microbial statistics, in compliance with the parameter automatic conversion characteristics of GB4789.2-2016.
（4）★Equipped with fast level set extraction technology, it can classify and count the number of colonies of specific colors and shapes according to 20 categories, and can be corrected by category conversion. Six target areas can be selected simultaneously for automatic analysis, and the analysis target areas can be freely increased, decreased, or edited.
(5) Automatically obtain colony area, equivalent diameter, major axis, minor axis, aspect ratio, roundness, perimeter, shape factor, etc. You can filter and query based on morphological indicators.
3★Measurement of inhibition zone and analysis of antibiotic potency
（1）One click fully automatic simultaneous measurement of 6 90mm diameter petri dishesAll the inhibition zones in the system can automatically determine the inhibition zone of local adhesion, and can automatically obtain results such as inhibition zone area and diameter in the presence of local text interference. Measurement and analysis take 1-4 seconds.
（2）The petri dish can be placed in any directionIt has the functions of automatic selection of antibacterial zone samples, faithful visualization comparison, and editing. The reading resolution of the antibacterial zone measurement system is ≤ 0.001mm, the highest optical measurement resolution is ≤ 0.0053mm, and the repeated measurement error is ≤± 0.016mm or ≤± 0.16%; The measurement error of potency is ≤± 0.15%; Repeated measurement error of potency ≤ ± 0.15%; The measurement difference between stations is ≤ 0.2%.
（3）Complies with the Chinese Pharmacopoeia, USP United States Pharmacopeia, and EP European PharmacopoeiaIt can complete the latest National Pharmacopoeia (2020 edition) dosage and combined calculation for the first, second, and third doses, as well as analyze the antibiotic potency of all strains. Combination optimization analysis characteristics with potency.
（4）Built in American CLSI "Antimicrobial Susceptibility Test Execution Standard"The latest 25th edition (2015) data provides a platform for data input and modification, facilitating updates and providing a quick tool for paper based drug susceptibility analysis.
(5) Can beAccording to the food additive Streptococcus lactiae QB 2394-2007 standardFully automatic simultaneous measurement of 24 or more inhibition zones and automatic analysis of potency.
4. Measurement function: Fully automatic size calibration, also available for manual calibration. Accurate measurement of length, angle, radian, area, arc, and any curve can be achieved by dragging with the mouse.
5. Export Query and Upgrade: The analysis of images and data results can be saved and reported directly without manual calculation. The results can be exported directly to Excel or PDF document reports. Has online upgrade feature.
6★Data traceability, permission protection, traceable operation records, in compliance with GLP and GMP requirementsAdopting a multi system architecture with separate functions and permissions to ensure the security, integrity, and authenticity of data information.
(1) System administrator: responsible for creating and managing accounts for all regular administrators and operators, and setting permissions for regular administrators and operators. There is only one system administrator who has the highest authority in the system.
(2) Ordinary administrator: responsible for reviewing and archiving all test data, as well as managing other system data. The system can assign multiple regular administrators, whose permissions are set and assigned by the system administrator.
(3) Operator: Responsible for sample production, testing, correction, generating electronic reports, submitting for review, etc. The system can assign multiple operators, whose permissions are set and assigned by the system administrator.
(4) All accounts can change their login password, set their own electronic signature, and output it to the report.
(5) The system automatically records the operation records of each account, and the system administrator can trace, view, and output the operation records.

3、 Standard configuration
1. HiCC-S1 fully automatic colony counting and inhibition zone measuring instrument system software USB flash drive and software lock 1 set
2. One 8-megapixel color camera with autofocus and a large depth of field
3. One dual light source color CCD scanning imaging device
4. 1 branded computer (Core i5 9th generation or above CPU/8GB memory/21.5 "color display/wireless network card, 4 or more USB 2.0 ports, running environment Windows 10 Full Professional Edition)
5. HiCC series automatic antibacterial zone measuring instrument dedicated standard board (with 1 authoritative calibration certificate attached) 1 piece

remarks:
1. In this technical proposal★The payment must be responsive, otherwise it is a significant deviation.
2. Optional Oxford cup placement plate (4-hole plate corresponds to two doses, 6-well plate corresponds to three doses), suitable for 90mm culture dishes and 7.8mm Oxford cups that comply with the new national pharmacopoeia.